Opelika is a city in and the county seat of Lee County in the east central part of the U.S. state of Alabama. It is a principal city of the Auburn-Opelika Metropolitan Area. According to 2008 Census estimates, the population of Opelika was 26,808. The Auburn-Opelika, Alabama MSA with a population of 130,516 which, along with the Columbus, Georgia-Alabama MSA and the Tuskegee, Alabama Micropolitan Statistical Area, comprises the greater Columbus-Auburn-Opelika, Georgia-Alabama Combined Statistical Area a region home to approximately 500,000 residents